Expression of a fibronectin in the dental pulp of lead intoxicated rats with experimentally induced diabetes mellitus

Introduction/Objective. Lead exposure represents one of the most important factors that affect general health, including oral health and it is associated with enamel dentin tooth defects. The aim this paper was to determine expression fibronectin in pulp rats experimentally induced diabetes mellitus (DM), after lead exposure, by using immunohistochemical analysis. Methods. study conducted on 42 Wistar strain. Intoxication lead-acetate done via drinking water ad libitum. first group (Exp_14) consisted 16 rats, which received for 14 days, second (Exp_30) 30 days at same concentration (1500 ppm), while control 10 healthy rats. Groups Exp_14 Exp_30 were into DM, Alloxan intraperitoneally. Pathohistological analysis determined pulp, odontoblasts, predentin dentine teeth. Results. High diffuse positivity noticed 63.6% 24% 50% There no statistically significant difference between examined groups. Conclusion. intoxication through water, a period had effect teeth animals DM.